Choosing between two items involves deliberation and comparison of the features of each item and its value. Such decisions take more time when choosing between options of similar value, possibly because these decisions require more evidence, but the mechanisms involved are not clear. We propose that the hippocampus supports deliberation about value, given its well-known role in prospection and relational cognition. We assessed the role of the hippocampus in deliberation in two experiments. First, using fMRI in healthy participants, we found that BOLD activity in the hippocampus increased as a function of deliberation time. Second, we found that patients with hippocampal damage exhibited more stochastic choices and longer reaction times than controls, possibly due to their failure to construct value based on internal evidence during deliberation. Both sets of results were stronger in value-based decisions compared to perceptual decisions.
The brain’s ability to preserve memories lies at the heart of our basic human experience. But what is its mechanism to make sure we remember the most significant events and keep our minds free of superfluous details?
According to a new study by Columbia University researchers, the brain plays back and prioritizes high-reward events for later retrieval and filters out the neutral, inconsequential events, retaining only memories that are useful to future decisions.
Published on Nov. 20 in the journal Nature Communications, the findings offer new insights into the mechanisms of both memory and decision making.
“Our memory is not an accurate snapshot of our experiences. We can’t remember everything,” said Daphna Shohamy, senior study author and principal investigator at Columbia's Mortimer B. Zuckerman Mind Brain Behavior Institute and a professor in the Department of Psychology. “One way the brain solves this problem is by automatically filtering our experiences, preserving memories of important information and allowing the rest to fade.”
The effect, however, is not immediate. “The prioritization of rewarding memories requires time for consolidation,” said study co-author Erin Kendall Braun, who conducted this research as part of her doctoral work in the Shohamy lab at the Zuckerman Institute and in psychology at Columbia’s Graduate School of Arts and Sciences. “Our findings suggest that the window of time immediately following the receipt of the reward – as well as a longer overnight window including sleep – work jointly to modulate the sequence of events and shape memory.”
To carry out their study, the researchers asked participants to explore a series of computer-simulated mazes looking for a hidden gold coin, for which they were paid one dollar. The maze was made up of a grid of grey squares, and as participants navigated it they were shown pictures of everyday objects, such as an umbrella or a mug. The researchers surprised participants with a test of their memory for these objects immediately afterwards.
When the memory test was given 24 hours later, participants remembered the objects closest to the reward (the gold coin) but not the others. This suggests the reward had a retroactive effect; memory for objects that had no special significance when initially seen were later recalled only because of their proximity to the reward. To the researchers’ surprise, this pattern was not found when they tested memory immediately. The brain needed time to prioritize memory for the events that led to the reward.
The test was replicated six times in different variations with a total of 174 participants, with similar results.
“The experiment demonstrates that what gets remembered isn’t random, and that the brain has mechanisms to automatically preserve memories important for future behavior,” said Shohamy. “For memories to be most useful for future decisions, we need them to be shaped by what matters, and it’s important that this shaping of memory happen before choices are made.”
Though the data provide insight into the structure of memory playback, how this happens in the human brain remains a mystery. The process probably involves dopamine, a chemical known to be important for signaling rewards, and the hippocampus, the brain region associated with long-term memory.
Further research is needed to understand the mechanism by which this occurs. An important follow-up question would be the effect of negative events on memory, a study “that would be a lot less fun for the participants,” said Shohamy. But like the current study, “it would help us understand how motivation affects memory and decision making. This understanding would have important implications for education and also for mental health.”
—By Carla Cantor
This paper is titled “Retroactive and Graded Prioritization of Memory by Reward.”
This research was supported by the National Institute of Health (5R01DA038891 to D.S.), the McKnight Foundation (MCKNGT CU16-0460 to D.S.) and the National Science Foundation (Career Award BCS-0955494 to D.S. and Graduate Research Fellowship DGE-1144155 to E.K.B.).
It’s no secret that the teen brain is unique, and recent research from Daphna Shohamy, a neuroscientist at Columbia's Zuckerman Institute, has confirmed striking differences in the brains of adolescents as compared to adults.
These differences shed light on the biology behind their reward-seeking behavior, and reveal that it actually evolved to help teens navigate the world around them during a pivotal time in their lives.
As millions of teens head back to the classroom, discover what the latest research into the adolescent brain reveals about how teens learn and interact with their environment — and whether this knowledge could help teachers better understand their students.
Congratulations to Dr. Erin Kendall Braun and Dr. Raphael Gerraty for successfully defending your dissertations!
We received the Templeton Foundation's: Templeton Science of Virtue Award as part of of multi-site center project to study "Understanding How Curiosity Drives Learning."
The lab received a grant from the Klarman Foundation to study "Mechanisms of Decision-making in Anorexia Nervosa: A Computational Psychiatry Approach"
Article by Laura Sanders in Science News on September 5th features research by Learning Lab graduate student Raphael Gerraty
Magazine issue: Vol. 192 No. 4, September 16, 2017, p. 22
WNET’s "Treasures of New York" aired on Sunday, June 15, an episode that explores the first building to open on Columbia’s new Manhattanville campus, the Jerome L. Greene Science Center.
Our lab is now located at Columbia’s 450,000-square-foot Jerome L. Greene Science Center, home to the Mortimer B. Zuckerman Mind Brain Behavior Institute, located on Broadway between 129th and 130th street.
Read more about our new location at https://zuckermaninstitute.columbia.edu
Congratulations to Akram Bakkour for being awarded the NSF SBE Postdoctoral Research Fellowship (SPRF)!
Congratulations to Raphael Gerraty for being awarded the National Research Service Award (NRSA) Predoctoral Training Fellowship (F31)!